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Preliminary experiments reveal conolidine could inhibit unique ion channels, minimizing neuronal excitability and restricting soreness signals. This mechanism is especially applicable in neuropathic pain, where irregular signaling will cause persistent soreness. Additionally, conolidine seems to influence G protein-coupled receptor (GPCR) pathways
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This compound was also tested for mu-opioid receptor activity, and like conolidine, was identified to obtain no action at the site. Utilizing a similar paw injection take a look at, various alternate options with bigger efficacy have been identified that inhibited the First pain response, indicating opiate-like exercise. Offered different mechanism
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